PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2318
Carbohydrate NameCore oligosaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeShigella flexneri serotype 1b   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe core is a single sequence of heptoses and hexoses
BCSDB StructureN/A
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesHeat killed cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MASF R3 core-1
Antibody type and classIgG2a
Assay SystemImmunoblotting, enzyme-linked immunosorbent assay (ELISA), hemagglutination, and coagglutination
Cross-reactivityThe core-specific antibodies were shown to be specific for the Escherichia coli R3 core, which all S. flexneri LPSs were found to have, except for S. flexneri serotype 6 LPS
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used for detection and identification of shigella flexneri species
Curator IDAA + AS
Date of Curation31-03-2011
References2424839


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