PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2216
Carbohydrate NameCore oligosaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeSalmonella choleraesuis SN57 [Ra]   (NCBI Taxonomy)   (Drugpedia)
Basic StructureLPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain
BCSDB StructureN/A
Proposed functionsLPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab MASC1-MM3
Antibody type and classIgM
Assay SystemEnzyme immunoassay, immunoblotting
Cross-reactivityThis Mab cross-reacted with with six different Salmonella core chemotypes S, Ra, Rb1, Rb2, Rb3, Rc and Rd1, the R2 core of Escherichia coli and a variety of smooth LPS
Proposed epitopesThe terminal disaccharide L-α-D-Hep1-->7-L-α-D-Hep1-O-me seemed to be the immunodominant epitope
IEDB EpitopeN/A
Proposed UtilityThis Mab would help elucidate the LPS core domain structure
Curator IDAA + AS
Date of Curation08-03-2011
References1383323


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