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| PolysacDB ID | 1040 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Chlamydia spp. (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LPS is composed of three parts: (1) lipid A, (2) core polysaccharide, and (3) O antigen. The lipid A region contains two glucosamine sugar derivatives, each with three fatty acids and phosphate or pyrophosphate attached. The core polysaccharide has KDO and attached to lipid A. The side chain O is small polysaccharide chain extending outward from the core, it has several peculiar sugars and varies in composition between bacterial strains. |
| BCSDB Structure | 116693 |
| Proposed functions | LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin |
| Antigenic Nature used to produce antibodies | Formalin killed L2 EBs |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L21-6 |
| Antibody type and class | IgG3 |
| Assay System | Immunobloting |
| Cross-reactivity | This antibody was cross-reactive with Re LPS of S.typhimurium. |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | Monoclonal antibody L21-6 recognizes chlamydal genus specific epitope. |
| Curator ID | AA + AS |
| Date of Curation | 12-01-2010 |
| References | PMC263518 |
| PolysacDB ID | 1357 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Chlamydia trachomatis serotype L2 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid) |
| BCSDB Structure | 4382 |
| Proposed functions | LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin |
| Antigenic Nature used to produce antibodies | Elementary bodies of Chlamydia trachomatis serotype L2 |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab L21-6 |
| Antibody type and class | IgG3 |
| Assay System | IFT assay, ELISA |
| Cross-reactivity | This antibody was specific only to C. psittaci LPS |
| Proposed epitopes | The epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO) |
| IEDB Epitope | 76828 |
| Proposed Utility | This Mab can be used in the epitope characterization of Chlamydial LPS |
| Curator ID | AA + AS |
| Date of Curation | 27-06-2010 |
| References | PMC258430 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |