PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us

Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2552
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae 01 34 Ogawa   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesPurified LPS
Carrier NameNil
Conjugation MethodNil
AntibodiesMab H8
Antibody type and classIgG3
Assay SystemEnzyme-linked immunosorbent assay inhibition experiments
Cross-reactivityThis Mab was specific to Ogawa 34 LPS only
Proposed epitopesThis Mab was specific to B antigen
IEDB EpitopeN/A
Proposed UtilityThis Mab had a good agglutinating capacity when tested against V. cholerae 0:1 strains
Curator IDAA + AS
Date of Curation24-06-2011
ReferencesPMC270838


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020