PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2551
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae 01 35 Inaba   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesPurified LPS
Carrier NameNil
Conjugation MethodNil
AntibodiesMab H4
Antibody type and classIgM
Assay SystemEnzyme-linked immunosorbent assay inhibition experiments
Cross-reactivityThis Mab reacted with Ogawa 34 and Inaba 35 serotype LPS but did not react with O2 LPS
Proposed epitopesThis Mab was specific to A antigen. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain
IEDB EpitopeN/A
Proposed UtilityThis Mab had a good agglutinating capacity when tested against V. cholerae 0:1 strains
Curator IDAA + AS
Date of Curation24-06-2011
ReferencesPMC270838


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