PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1180
Carbohydrate NameLipoologosaccharide band A of the LPS   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeBordetella pertusis 114   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsThe LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties
Antigenic Nature used to produce antibodiesPartially purified preparations of fimbriae from B. pertussis 114
Carrier NameNil
Conjugation MethodNil
AntibodiesMab G1OF8C3
Antibody type and classIgG3
Assay SystemImmunoblotting
Cross-reactivityFour strains of Bordetella bronchiseptica and three strains of Bordetella parapertussis were not agglutinated, nor were other gram-negative bacteria, such as Escherichia coli, N.meningitidis, Neisseria gonorrhoeae, Salmonella typhimurium, and Haemophilus influenzae
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab specifically agglutinated the bacteria. It could be useful in establishing a better-defined serotyping system for B. pertussis in which LOS A might be considered a typing antigen. This Mab can also be useful for the estimation of contaminating levels of endotoxin in vaccine preparations and for further studies on the structure of B. pertussis LOS.
Curator IDAA + AS
Date of Curation27-02-2010
ReferencesPMC259348


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020