| PolysacDB ID | 1171 |
| Carbohydrate Name | Lipoologosaccharide band A of the LPS (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Bordetella pertusis (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B
|
| BCSDB Structure | N/A |
| Proposed functions | The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties |
| Antigenic Nature used to produce antibodies | N/A |
| Carrier Name | N/A |
| Conjugation Method | N/A |
| Antibodies | Mab G10F8C3 |
| Antibody type and class | IgG3 |
| Assay System | Immunoblotting, Protein A sepharose affinity chromatography, bactericidal assays |
| Cross-reactivity | This antibody was specific to B. pertusis strains |
| Proposed epitopes | This Mab reacts with the core oligosaccharide moeity |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab exhibits complement dependent bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition it was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection |
| Curator ID | AA + AS |
| Date of Curation | 25-02-2010
|
| References | PMC258314 |