| PolysacDB ID | 1037 |
| Carbohydrate Name | Galactomannan (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Aspergillus fumigatus (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Galactomannan is composed of a branched core containing α(1-->2)- and α(1-->6)-linked mannose, with β(1-->5)galactofuranose and/or β(1-->4)galactopyranose moieties linked linearly in side chains terminated by galactofuranose nonreducing end units
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| BCSDB Structure | N/A |
| Proposed functions | Galactomannan is a major cell wall component in Aspergillusspecies and can also be secreted into the medium as a component of the exoantigen. The galactomannan is immunogenic and polyclonal antibodies against it have been used in antigen detection for the diagnosis of invasive aspergillosis, and in the detection of fungal contamination in foodstuffs |
| Antigenic Nature used to produce antibodies | Formalinized spores of A. fumigatus. |
| Carrier Name | N/A |
| Conjugation Method | N/A |
| Antibodies | Mab EB-A2 |
| Antibody type and class | IgM |
| Assay System | Indirect and Competitive ELISA |
| Cross-reactivity | This antibody cross-reacted to P. digitatum and Penicillium marneffei speices. |
| Proposed epitopes | 3(1-->5)galactofuranose residues of galactomannan |
| IEDB Epitope | N/A |
| Proposed Utility | EB-A2 has been used to detect circulating antigen in the serum of patients with invasive aspergillosis by ELISA inhibition. The sensitivity (95%), specificity (100%), positive predictive value (100%), and negative predictive value (99%)of the ELISA |
| Curator ID | AA + AS |
| Date of Curation | 10-01-2010
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| References | PMC257149 |