PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID2507
Carbohydrate NameCore oligosaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeVibrio cholerae 01 serogroup   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsV. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodiesPurified LPS
Carrier NameNil
Conjugation MethodNil
AntibodiesMab E8
Antibody type and classIgG1
Assay SystemEnzyme-linked immunosorbent assayinhibition experiments, Coagglutination experiments
Cross-reactivityThis Mab cross-reacted with both 0-group 1 vibrios and some non-O-group 1 vibrios
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab may provide improved opportunities for the characterization of antigenic determinants
Curator IDAA + AS
Date of Curation09-06-2011
ReferencesPMC347760


Entry No. - 2   [TOP]
PolysacDB ID2585
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeRhizobium leguminosarum biovar trifolii strain 162X95   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsStructural modifications of Rhizobium LPS may play an important role in the adaptation of endosymbiotic rhizobia to the surrounding microenvironment
Antigenic Nature used to produce antibodiesHeat treated cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab E8
Antibody type and classIgG3
Assay SystemCompetitive enzyme-linked immunosorbent assay, ELISA, immunoblotting
Cross-reactivityThis MAb to the O antigen of R. trifolii 162X95 has been shown to be specific for six strains of R. trifolii only
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used for immunodetection of R. trifolii
Curator IDAA + AS
Date of Curation08-07-2011
ReferencesPMC184596


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