| PolysacDB ID | 1831 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Neisseria gonorrhoeae strain 4505 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | Gonococcal lipopolysaccharide (LPS) is a complex of at least three major antigenic determinants. The ceramide part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/. The core oligosaccharide part consists of the following residues : α-D-GlcpNAc-(1-->2)-L-gro [branched to β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)] -α-D-manHepp-(1-->3)-L-gro-α-D-manHepp-(1-->5)-Kdo. The other part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-GlcpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)-L-gro [branched to α-D-GlcpNAc-(1-->2)-L-gro-α-D-manHepp-(1-->3)] -α-D-manHepp-(1-->5)-Kdo
|
| BCSDB Structure | N/A |
| Proposed functions | It is an important virulence factor |
| Antigenic Nature used to produce antibodies | Heat-killed gonococcal strain 4505 cells |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 3F11 |
| Antibody type and class | IgG1 |
| Assay System | ELISA |
| Cross-reactivity | This Mab cross-reacted with meningococcal LPS but failed to react with LPS isolated from Escherichia coli 0:111, the J-5 mutant of E. coli 0:111, or Salmonella minnesota R595 |
| Proposed epitopes | D-galactosamine, α and β lactose residues seemed to be the part of the epitope |
| IEDB Epitope | N/A |
| Proposed Utility | This Mab may be used for epitope elucidation of gonococcal LPS |
| Curator ID | AA + AS |
| Date of Curation | 11-11-2010
|
| References | PMC350935 |