PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID1510
Carbohydrate NameLipopolysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus pleuropneumoniae serotype b strains 81-750 and B78-3760   (NCBI Taxonomy)   (Drugpedia)
Basic StructureO-polysaccharide structure of strain 81-750 is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsLPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus
Antigenic Nature used to produce antibodiesFormaldehyde killed cells of strains 81-750 and B78-3760 and LPS coated whole cells of strain 81-750.
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 3B4
Antibody type and classIgG1
Assay SystemELISA and dot ELISA
Cross-reactivityThis antibody cross-reacted strongly with CPS of serotype 5b
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used to detect the presence of bacterial antigens in lungs from infected animals
Curator IDAA + AS
Date of Curation08-08-2010
ReferencesPMC1263782


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