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| PolysacDB ID | 1392 |
| Carbohydrate Name | Lipopolysaccharide (Drugpedia) |
| Carbohydrate Class | Lipopolysaccharide |
| Microbe | Salmonella minnesota R595 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo |
| BCSDB Structure | N/A |
| Proposed functions | LPS plays an important virulence role based on its antiphagocytic and endotoxic properties |
| Antigenic Nature used to produce antibodies | Acid-treated and lipid A-coated S. minnesota R597 |
| Carrier Name | Nil |
| Conjugation Method | Nil |
| Antibodies | Mab 1F2 |
| Antibody type and class | IgG1 |
| Assay System | ELISA, immunoblotting and RIA |
| Cross-reactivity | This antibody cross-reacted with E. coli J5, , S. minnesota R595, but did not cross-react with Staphylococcus aureus, E. Coli O111:B4, K. pneumoniae, S. marcescens and P. Aeruginosa and Staphylococcus faecalis |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 07-07-2010 |
| References | PMC260436 |
| PolysacDB ID | 1974 |
| Carbohydrate Name | Capsular polysaccharide (Drugpedia) |
| Carbohydrate Class | Capsular polysaccharide |
| Microbe | Streptococcus pneumoniae strain 14 (NCBI Taxonomy) (Drugpedia) |
| Basic Structure | The capsular polysaccharide consists of the following residues : -6)-β-D-GlcpNAc [branched to β-D-Galp-(1-->4)] -(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1- |
| BCSDB Structure | 2848 |
| Proposed functions | N/A |
| Antigenic Nature used to produce antibodies | Glycoconjugates |
| Carrier Name | Tetanus toxoid |
| Conjugation Method | The oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid |
| Antibodies | Mab 1F2 |
| Antibody type and class | IgG1 |
| Assay System | Enzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay |
| Cross-reactivity | This Mab was specific tgo strain 14 and did not cross-react with other strains |
| Proposed epitopes | N/A |
| IEDB Epitope | N/A |
| Proposed Utility | N/A |
| Curator ID | AA + AS |
| Date of Curation | 08-12-2010 |
| References | PMC95896 |
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Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |