PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1398
Carbohydrate NameGP25-200 antigen   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobeCryptosporidium parvum   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesImmunoaffinity purified GP25-200 antigen
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 1B3
Antibody type and classIgM
Assay SystemELISA, immunoblotting, immunofluorescence and invivo protection assays
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab was able to neutralize cryptosporidium infection
Curator IDAA + AS
Date of Curation10-07-2010
ReferencesPMC97466


Entry No. - 2   [TOP]
PolysacDB ID1506
Carbohydrate NameCapsular polysaccharide   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeActinobacillus pleuropneumoniae serotype b strain 81-750   (NCBI Taxonomy)   (Drugpedia)
Basic StructureConsists of a common backbone consisting of disaccharide repeating units, [->6)-α-DGlcpNAc (1-->5)-β-Kdop-(2-->]n, but, in addition, the CPS of serotype 5b has a lateral β-D-glucopyranosyl residue
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesFormaldehyde killed cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 1B3
Antibody type and classIgM
Assay SystemELISA and dot ELISA
Cross-reactivityThis antibody cross-reacted strongly with strain CPS of serotype 5b
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used to detect the presence of bacterial antigens in lungs from infected animals
Curator IDAA + AS
Date of Curation07-08-2010
ReferencesPMC1263782


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