PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 2

Entry No. - 1   [TOP]
PolysacDB ID1504
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus pleuropneumoniae serotype b strain 81-750   (NCBI Taxonomy)   (Drugpedia)
Basic StructureIt is a linear unbranched homopolymer of 1,6-linked-D-galactopyranosyl residues.
BCSDB StructureN/A
Proposed functionsLPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus
Antigenic Nature used to produce antibodiesFormaldehyde killed cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 1A3
Antibody type and classIgM
Assay SystemELISA and dot ELISA
Cross-reactivityThis antibody cross-reacted strongly with strain L20 CPS (serotype 5b)
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab can be used to detect the presence of bacterial antigens in lungs from infected animals
Curator IDAA + AS
Date of Curation06-08-2010
ReferencesPMC1263782


Entry No. - 2   [TOP]
PolysacDB ID1928
Carbohydrate NameUnknown carbohydrate   (Drugpedia)
Carbohydrate ClassGlycoprotein
MicrobePythium porphyrae   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameNil
Conjugation MethodNil
AntibodiesMab 1A3
Antibody type and classIgM
Assay SystemELISA, immunofluorscence assay, immunoblotting
Cross-reactivityThis Mab recognized all the isolates of Py. Porphyrae but did not react with the spore components of the higher plant-infecting oomycetes or the obligate parasite Olpidiopsis sp. Infecting Porphyra spp
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab induced zoospore encystment under in vitro conditions
Curator IDAA + AS
Date of Curation30-11-2010
References


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020