|
|
Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us |
|
PolysacDB ID | 1207 |
Carbohydrate Name | Smooth Lipopolysaccharide (Drugpedia) |
Carbohydrate Class | Lipopolysaccharide |
Microbe | Brucella melitensis strain B115 (NCBI Taxonomy) (Drugpedia) |
Basic Structure | The S-LPS of smooth-type Brucella spp. contains two distinct antigenic determinants designated A and M |
BCSDB Structure | N/A |
Proposed functions | LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin |
Antigenic Nature used to produce antibodies | Whole cells |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab 14f12 |
Antibody type and class | IgG1 |
Assay System | ELISA and immunoblotting |
Cross-reactivity | This antibody was specific to a common epitope on A and M polysaccharides. This Mab cross-reacted with O-PS of B. abortus 99 but did not bind to R-LPS of B. melitensis B11; also did not cross-react with Y. enterocolitica0:9 LPS |
Proposed epitopes | Both α1-->2 and α1-->3 linkages seem to be an important part of the epitope |
IEDB Epitope | N/A |
Proposed Utility | This mAb may be particularly useful for typingsmooth Brucella strains |
Curator ID | AA + AS |
Date of Curation | 08-03-2010 |
References | 1382111 |
PolysacDB ID | 1303 |
Carbohydrate Name | Phosphomannan protein complex (Drugpedia) |
Carbohydrate Class | Glycoprotein |
Microbe | Candida albicans NIH B-792 (NCBI Taxonomy) (Drugpedia) |
Basic Structure | N/A |
BCSDB Structure | N/A |
Proposed functions | N/A |
Antigenic Nature used to produce antibodies | Heat-killed yeast-form cells of Candida albicans NIH B-792 strain |
Carrier Name | Nil |
Conjugation Method | Nil |
Antibodies | Mab 14f12 |
Antibody type and class | IgM |
Assay System | N/A |
Cross-reactivity | This antibody cross-reacted with NIH A-207 (serotype A) and J-1012 [serotype A] and C. tropicalis IFO 0610 |
Proposed epitopes | The epitope was proposed to contain β-1,2-linked oligomannosyl residues |
IEDB Epitope | N/A |
Proposed Utility | Antibodies to β- 1,2-linked oligomannosyl residues can be used as the serodiagnostic agent for detecting the C. albicans antigen(s) in sera and tissues of mammals with candidiasis. |
Curator ID | AA + AS |
Date of Curation | 27-05-2010 |
References | 3280163 |
Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020 |