PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

Home | Search | Advance Search | Browse | Online Submission | Documentation & FAQ | Team | Contact us
Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 1

Entry No. - 1   [TOP]
PolysacDB ID2612
Carbohydrate NameGlucurunoxylomannan   (Drugpedia)
Carbohydrate ClassCapsular polysaccharide
MicrobeCryptococcus neoformans serotype A   (NCBI Taxonomy)   (Drugpedia)
Basic StructureThe capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
BCSDB Structure116826
Proposed functionsThe capsular polysaccharide is an important virulence factor
Antigenic Nature used to produce antibodiesGlycoconjugates
Carrier NameSheep erythrocytes
Conjugation MethodThe capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
AntibodiesMab 1326
Antibody type and classIgG1
Assay SystemELISA
Cross-reactivityThis antibody was cross-reactive to serotypes A and D
Proposed epitopesN/A
IEDB Epitope115576
Proposed UtilityThis monoclonal antibody promoted opsonization of Cryptococcus cells
Curator IDAA + AS
Date of Curation18-07-2011
References1583327


Department of Computational Biology, Indraprastha Institute of Information Technology, Sec - 39A, New Delhi, India - 110020