PolysacDB: A comprehensive database of microbial polysaccharide antigens and their antibodies

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Citation: Aithal A, Sharma A, Joshi S, Raghava GPS, Varshney GC (2012) PolysacDB: A Database of Microbial Polysaccharide Antigens and Their Antibodies. PLoS ONE 7(4): e34613. doi:10.1371/journal.pone.0034613
Total Entries - 3

Entry No. - 1   [TOP]
PolysacDB ID2651
Carbohydrate NameSerotype b-specific polysaccharide antigen   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus actinomycetemcomitans Y4   (NCBI Taxonomy)   (Drugpedia)
Basic StructureSerotype b-specific antigen of A. actinomycetemcomitans is a capsular polysaccharide-like antigen consisting of a disaccharide repeating unit, 33)-a-D-fucopyranosyl-(132)-b-L-rhamnopyranosyl-(1-
BCSDB StructureN/A
Proposed functionsSPA of A. actinomycetemcomitans plays an important role in the resistance to phagocytosis and killing by human PMNs.
Antigenic Nature used to produce antibodiesWhole cells
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgM
Antibody type and classMab S9
Assay SystemChemiluminescence (CL) assay, immunoblotting and phagocytic killing assay
Cross-reactivityN/A
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis Mab did not enhance CL responses of human PMNs to the organism and did not promote killing of the organism by human PMNs
Curator IDAA + AS
Date of Curation25-01-2012
ReferencesPMC173659


Entry No. - 2   [TOP]
PolysacDB ID2652
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus pleuropneumoniae serotype 7   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodies0.2% formalinized whole cell antigens
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgM
Antibody type and classMab 7.1.9D4E4
Assay SystemDot-ELISA, ELISA-inhibition test
Cross-reactivityThis mab reacted only with reference strains of A. pleuropneumoniae serotypes 7 and 4. It also cross-reacted strongly with A. lignieresii
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis mab was shown to be suitable for serotyping since they detected 100% of serotype 7 strains
Curator IDAA + AS
Date of Curation26-01-2012
References10223326


Entry No. - 3   [TOP]
PolysacDB ID2654
Carbohydrate NameO-polysaccharide   (Drugpedia)
Carbohydrate ClassLipopolysaccharide
MicrobeActinobacillus pleuropneumoniae serotype 7   (NCBI Taxonomy)   (Drugpedia)
Basic StructureN/A
BCSDB StructureN/A
Proposed functionsN/A
Antigenic Nature used to produce antibodies0.2% formalinized whole cell antigens
Carrier NameN/A
Conjugation MethodN/A
AntibodiesIgM
Antibody type and classMab 7.1.3D5G4
Assay SystemDot-ELISA, ELISA-inhibition test
Cross-reactivityThis mab reacted only with reference strains of A. pleuropneumoniae serotypes 7. It also cross-reacted strongly with A. lignieresii
Proposed epitopesN/A
IEDB EpitopeN/A
Proposed UtilityThis mab was shown to be suitable for serotyping since they detected 100% of serotype 7 strains
Curator IDAA + AS
Date of Curation26-01-2012
References10223326


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