ParaPep -A Database of Anti-parasitic peptides
Detailed description page of ParaPep |
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1622 details |
| Primary information | |||||||||||||||||
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| ParaPep ID | 1622 | ||||||||||||||||
| PMID | 18657321 | ||||||||||||||||
| YEAR | 2008 | ||||||||||||||||
| SEQUENCE | DCLSGRYKGPCAVWDNETCRRVCKEEGRSSGHCSPSLKCWCEGC | ||||||||||||||||
| LENGTH | 44 | ||||||||||||||||
| NAME | Drosomycin | ||||||||||||||||
| C-ter Modification | Free | ||||||||||||||||
| N-ter Modification | Free | ||||||||||||||||
| Linear/Cyclic | Linear | ||||||||||||||||
| Stereochemistry | L | ||||||||||||||||
| Chemical Modification | None | ||||||||||||||||
| Disease | Malaria | ||||||||||||||||
| Assay | Microscopy (Giemsa staining) | ||||||||||||||||
| Parasite Type | Plasmodium berghei ANKA 2.34 (ookinetes) | ||||||||||||||||
| In-vivo/vitro | In vitro | ||||||||||||||||
| Activity | 70-80%inhibition at 10 to 20 μM | ||||||||||||||||
| Hemolysis | Not reported | ||||||||||||||||
| Nature | Antifungal | ||||||||||||||||
| Secondary information | |||||||||||||||||
| STRUCTURE |
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| DSSP states | CCCTTCBCCSSSSCBCHHHHHTTTSSSCTTCSSSCCSSCCCSCC | ||||||||||||||||
| SMILES | N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)O | ||||||||||||||||
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