Detailed description page of ParaPep |
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1400 details |
Primary information | |||||||||||||||||
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ParaPep ID | 1400 | ||||||||||||||||
PMID | 3049204 | ||||||||||||||||
YEAR | 1988 | ||||||||||||||||
SEQUENCE | MPRWRLFRRIDRVGKQIKQGILRAGPAIALVGDARAVG | ||||||||||||||||
LENGTH | 38 | ||||||||||||||||
NAME | Shiva-1 | ||||||||||||||||
C-ter Modification | Free | ||||||||||||||||
N-ter Modification | Free | ||||||||||||||||
Linear/Cyclic | Linear | ||||||||||||||||
Stereochemistry | L | ||||||||||||||||
Chemical Modification | None | ||||||||||||||||
Disease | Malaria | ||||||||||||||||
Assay | [3H] Hypoxanthine incorporation assay | ||||||||||||||||
Parasite Type | Plasmodium falciparum Sierra- Leone1/CDC isolate | ||||||||||||||||
In-vivo/vitro | In vitro | ||||||||||||||||
Activity | IC50=50 μM | ||||||||||||||||
Hemolysis | Not reported | ||||||||||||||||
Nature | Lytic peptide | ||||||||||||||||
Secondary information | |||||||||||||||||
STRUCTURE |
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DSSP states | CCCCTTTTHHHHHHHHHTTCTTSCCCSSSSCCSTTTCC | ||||||||||||||||
SMILES | N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C1=N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)OO1 | ||||||||||||||||
External Links | |||||||||||||||||
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