ParaPep -A Database of Anti-parasitic peptides
Detailed description page of ParaPep |
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1131 details |
| Primary information | |||||||||||||||||
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| ParaPep ID | 1131 | ||||||||||||||||
| PMID | 16460023 | ||||||||||||||||
| YEAR | 2006 | ||||||||||||||||
| SEQUENCE | FKIKPGKVLDKFGKIVGKVLKQLKKVSAVAKV | ||||||||||||||||
| LENGTH | 32 | ||||||||||||||||
| NAME | Trialysin peptide P6 | ||||||||||||||||
| C-ter Modification | Amidation | ||||||||||||||||
| N-ter Modification | Free | ||||||||||||||||
| Linear/Cyclic | Linear | ||||||||||||||||
| Stereochemistry | L | ||||||||||||||||
| Chemical Modification | None | ||||||||||||||||
| Disease | Chagas | ||||||||||||||||
| Assay | Microscopy (Surviving parasites counted by Neubauer hemocytometer) | ||||||||||||||||
| Parasite Type | Trypanosoma cruzi | ||||||||||||||||
| In-vivo/vitro | In vitro | ||||||||||||||||
| Activity | LC50=0.4 μM | ||||||||||||||||
| Hemolysis | LC50=90 μM | ||||||||||||||||
| Nature | Cytolytic | ||||||||||||||||
| Secondary information | |||||||||||||||||
| STRUCTURE |
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| DSSP states | CCCCCTTCSHHHHHHHHHHHHHHHHHTTCSCC | ||||||||||||||||
| SMILES | N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N=CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N | ||||||||||||||||
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