A database of hormones and their receptors
Receptor

Search Result - 1

HMRbase accession number21106
Swiss-prot Accession numberQ5XM32 (Sequence in FASTA format)
DescriptionRelaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (INSL3 receptor).
Source organismCanis familiaris (Dog)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis.
Subcellular locationCell membrane; Multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats.
Tissue SpecificityN/A
Post translational modification N/A
Function Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).
Protein Length737 Amino acids
Molecular weight84109
Domain NameLRR_1  7tm_1  Ldl_recept_a  
References1   Agoulnik A.I.; Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
HormoneQ9TRM8   Detail in HMRbase   
Gene ID450220      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 2

HMRbase accession number21165
Swiss-prot Accession numberQ91ZZ5 (Sequence in FASTA format)
DescriptionRelaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (G-protein coupledreceptor affecting testicular descent) (G-protein coupled receptor106).
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationCell membrane; Multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats.
Tissue SpecificityExpressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart.
Post translational modificationN/A
Function Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).
Protein Length737 Amino acids
Molecular weight82944
Domain NameLRR_1  7tm_1  Ldl_recept_a  
References1  PubMed abstract 11353515
HormoneP47932   Detail in HMRbase   
Q8CHK2   Detail in HMRbase   
Gene ID140498      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 3

HMRbase accession number21187
Swiss-prot Accession numberQ9HBX9 (Sequence in FASTA format)
DescriptionRelaxin receptor 1 (Relaxin family peptide receptor 1) (Leucine-richrepeat-containing G-protein coupled receptor 7).
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationCell membrane; Multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats.
Tissue SpecificityExpressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.
Post translational modificationN/A
Function Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Protein Length757 Amino acids
Molecular weight86993
Domain NameLRR_1  7tm_1  Ldl_recept_a  
References1  PubMed abstract 10935549
2  PubMed abstract 11517286
3  PubMed abstract 12506116
HormoneP04090   Detail in HMRbase   
P04808   Detail in HMRbase   
Q8WXF3   Detail in HMRbase   
Gene ID59350      
PDB ID2JM4      
Drugpediawiki
Comments