A database of hormones and their receptors |
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HMRbase accession number | 21106 |
Swiss-prot Accession number | Q5XM32 (Sequence in FASTA format) |
Description | Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (INSL3 receptor). |
Source organism | Canis familiaris (Dog) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
Subcellular location | Cell membrane; Multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). |
Protein Length | 737 Amino acids |
Molecular weight | 84109 |
Domain Name | LRR_1 7tm_1 Ldl_recept_a |
References | 1 Agoulnik A.I.; Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
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Hormone | Q9TRM8 Detail in HMRbase |
Gene ID | 450220 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21165 |
Swiss-prot Accession number | Q91ZZ5 (Sequence in FASTA format) |
Description | Relaxin receptor 2 (Relaxin family peptide receptor 2) (Leucine-richrepeat-containing G-protein coupled receptor 8) (G-protein coupledreceptor affecting testicular descent) (G-protein coupled receptor106). |
Source organism | Mus musculus (Mouse) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
Subcellular location | Cell membrane; Multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart. |
Post translational modification | N/A |
Function | Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity). |
Protein Length | 737 Amino acids |
Molecular weight | 82944 |
Domain Name | LRR_1 7tm_1 Ldl_recept_a |
References | 1 PubMed abstract 11353515 |
Hormone | P47932 Detail in HMRbase Q8CHK2 Detail in HMRbase |
Gene ID | 140498 |
PDB ID | N/A |
Drugpedia | wiki |
Comments |
HMRbase accession number | 21187 |
Swiss-prot Accession number | Q9HBX9 (Sequence in FASTA format) |
Description | Relaxin receptor 1 (Relaxin family peptide receptor 1) (Leucine-richrepeat-containing G-protein coupled receptor 7). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Cell membrane; Multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. Contains 1 LDL-receptor class A domain. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. |
Post translational modification | N/A |
Function | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
Protein Length | 757 Amino acids |
Molecular weight | 86993 |
Domain Name | LRR_1 7tm_1 Ldl_recept_a |
References | 1 PubMed abstract 10935549 2 PubMed abstract 11517286 3 PubMed abstract 12506116 |
Hormone | P04090 Detail in HMRbase P04808 Detail in HMRbase Q8WXF3 Detail in HMRbase |
Gene ID | 59350 |
PDB ID | 2JM4 |
Drugpedia | wiki |
Comments |