A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20172 |
| Swiss-prot Accession number | A0EQL2 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG). |
| Source organism | Crocuta crocuta (Spotted hyena) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Hyaenidae;Crocuta. |
| Subcellular location | Secreted protein (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity) |
| Developmental Stage | N/A |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). |
| Protein Length | 393 Amino acids |
| Molecular weight | 42443 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 Miguel-Queralt S., Yalcinkaya T.M., Avvakumov G.V., Place N.,Siiteri P.K., Glickman S.E., Hammond G.L.; "Unusual steroid-binding properties of hyena sex hormone-bindingglobulin."; Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
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| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 20173 |
| Swiss-prot Accession number | P04278 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP)(Testosterone-estrogen-binding globulin) (Testosterone-estradiol-binding globulin) (TeBG). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity) |
| Developmental Stage | N/A |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | Isoforms 1 and 2 are present in liver and testis. |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. |
| Protein Length | 402 Amino acids |
| Molecular weight | 43779 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 2587256 2 PubMed abstract 2608061 3 PubMed abstract 15489334 4 PubMed abstract 3569533 5 PubMed abstract 2956126 6 PubMed abstract 2956125 7 PubMed abstract 3702459 8 PubMed abstract 3542030 9 PubMed abstract 16335952 10 PubMed abstract 1400872 11 PubMed abstract 10675319 12 PubMed abstract 12065592 13 PubMed abstract 7714097 14 PubMed abstract 10391209 15 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
| Hormone | N/A |
| Gene ID | 6462 |
| PDB ID | 1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 20174 |
| Swiss-prot Accession number | P97497 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity) |
| Developmental Stage | N/A |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). |
| Protein Length | 403 Amino acids |
| Molecular weight | 44816 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 2753230 |
| Hormone | N/A |
| Gene ID | 20415 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 20175 |
| Swiss-prot Accession number | Q62588 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP). |
| Source organism | Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Cricetidae; Cricetinae; Phodopus. |
| Subcellular location | Secreted protein (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity) |
| Developmental Stage | N/A |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | N/A |
| Post translational modification | Differentially glycosylated in liver (SHBG) and testis (ABP). |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). |
| Protein Length | 399 Amino acids |
| Molecular weight | 43842 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 7495693 2 PubMed abstract 9462298 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 20176 |
| Swiss-prot Accession number | P15196 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP). |
| Source organism | Oryctolagus cuniculus (Rabbit) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus. |
| Subcellular location | Secreted protein (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity) |
| Developmental Stage | N/A |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). |
| Protein Length | 398 Amino acids |
| Molecular weight | 43154 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 9203991 2 PubMed abstract 10746639 3 PubMed abstract 2808412 4 Yarbrough W.G., Welch J.E., Joseph D.R.; Submitted (AUG-1988) to the EMBL/GenBank/DDBJ databases. |
| Hormone | N/A |
| Gene ID | 100009224 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
| HMRbase accession number | 20177 |
| Swiss-prot Accession number | P08689 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis |
| Developmental Stage | In the fetal liver, expressed from day 14 to day 17 after conception. |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | Isoform 2 is only expressed in the liver. |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). |
| Protein Length | 403 Amino acids |
| Molecular weight | 44533 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 2432609 2 PubMed abstract 2840566 3 PubMed abstract 15489334 4 PubMed abstract 1702422 5 PubMed abstract 3135485 6 PubMed abstract 1855466 |
| Hormone | N/A |
| Gene ID | 24775 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |