A database of hormones and their receptors
Receptor

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HMRbase accession number21427
Swiss-prot Accession numberP57797 (Sequence in FASTA format)
DescriptionPeroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name: Nuclear receptor subfamily 1 group C member 3
Source organismCricetulus griseus (Chinese hamster)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Cricetidae; Cricetinae; Cricetulus.
Subcellular locationNucleus
Developmental StageN/A
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue SpecificityN/A
Post translational modification N/A
Function Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
Protein Length475 Amino acids
Molecular weight54473
Domain NameHormone_recep  zf-C4  
References1  PubMed abstract 7557447
HormoneDetail in HMRbase   
Gene IDN/A
PDB IDN/A
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