A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21478 |
| Swiss-prot Accession number | Q7SYN5 (Sequence in FASTA format) |
| Description | Retinoic acid receptor RXR-beta-A;Alternative Name: Retinoid X receptor beta-A;Alternative Name: Nuclear receptor subfamily 2 group B member 2-A |
| Source organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;Cyprinidae; Danio. |
| Subcellular location | Nucleus |
| Developmental Stage | Expressed both maternally and zygotically. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Shows uniform expression from the blastula to mid-gastrula stages. At 12 hours post-fertilization (hpf), expressed ubiquitously but more weakly. At 24 hpf, restricted to the ventral diencephalon, pharangeal endoderm and trunk and tail mesoderm; mesoderm expression is in medial cells of each somite along the dorsoventral axis, forming stripes. At 48 hpf, expressed in forebrain, eye, midbrain and anterior hindbrain. |
| Post translational modification | N/A |
| Function | Nuclear hormone receptor. Involved in the retinoic acid response pathway. Does not bind 9-cis retinoic acid (9C-RA). Transcriptionally inactive on RXR response elements. May function to positively modulate thyroid hormone-dependent transcription. |
| Protein Length | 471 Amino acids |
| Molecular weight | 51597 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7565671 2 PubMed abstract 9192646 3 PubMed abstract 16448862 |
| Hormone | N/A |
| Gene ID | 30530 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |