A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21464 |
| Swiss-prot Accession number | P35398 (Sequence in FASTA format) |
| Description | Nuclear receptor ROR-alpha;Alternative Name: Retinoid-related orphan receptor-alpha;Alternative Name: Nuclear receptor RZR-alpha;Alternative Name: Nuclear receptor subfamily 1 group F member 1 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. |
| Protein Length | 556 Amino acids |
| Molecular weight | 63036 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7926749 2 PubMed abstract 7916608 3 PubMed abstract 15489334 4 PubMed abstract 16959974 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 6095 |
| PDB ID | 1N83 1S0X |
| Drugpedia | wiki |
| Comments |