A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21415 |
| Swiss-prot Accession number | Q66JK1 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 6 group A member 1;Alternative Name: Germ cell nuclear factor;GCNF |
| Source organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Silurana. |
| Subcellular location | Cytoplasm (By similarity). Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR6 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3'. Required for anterior-posterior patterning during organogenesis. Acts with chordin to play a role in patterning the midbrain-hindbrain. Isoform Em is required for integrin-mediated cell matrix interaction during neurulation and for the morphogenetic movements leading to formation of the neural tube. Also mediates the effect of retinoic acid on primary neurogenesis (By similarity). |
| Protein Length | 435 Amino acids |
| Molecular weight | 50010 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 12351198 |
| Hormone | N/A |
| Gene ID | 493367 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |