A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21378 |
| Swiss-prot Accession number | Q505F1 (Sequence in FASTA format) |
| Description | RecName: Nuclear receptor subfamily 2 group C member 1;Alternative Name: Orphan nuclear receptor TR2;Alternative Name: Testicular receptor 2;mTR2 |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | Isoform 1 is highly expressed in early to midgestation embryos, with expression leveling off during stage E15. After birth, expression in the testes remains at a basal level until puberty, begins to increase at postnatal day 16 and peaks at postnatal days 20 to 24. Expression is maintained at a high level throughout adulthood. Isoform 2 peaks transiently at postnatal day 24. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Isoform 1 is highly expressed in the adlumenal compartment of the seminiferous tubule of adult testes (at protein level) and in the eyes of newborn animals. Weakly expressed in other adult organs including the seminal vesicle, prostate, ovary, adrenal gland, heart, thymus, placenta and brain. Expressed during the embryonic stages in developing eyes, brain and cartilage primordia (at protein level). Also expressed in the developing spinal motor neurons and in the sympathetic-, parasympathetic- and sensory ganglia of the embryonic PNS. Expressed in the developing neural epithelia of the inner ear, nasal cavity, tongue and retina. In contrast, isoform 2 is widely expressed at a low level throughout the adult testis. |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor. Isoform 1 represses transcription and binds DNA as a homodimer. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. |
| Protein Length | 590 Amino acids |
| Molecular weight | 65506 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 8595902 2 PubMed abstract 8858600 3 PubMed abstract 9071982 4 PubMed abstract 9504722 5 PubMed abstract 9694834 6 PubMed abstract 16141072 7 PubMed abstract 15489334 8 PubMed abstract 9369481 9 PubMed abstract 9774688 10 PubMed abstract 11463856 |
| Hormone | N/A |
| Gene ID | 22025 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |