| HMRbase accession number | 20795 |
| Swiss-prot Accession number | Q28997 (Sequence in FASTA format) |
| Description | Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Palmitoylated; may reduce accessibility of Ser-345 and Ser- 346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation (By similarity). Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA- mediated phosphorylation seems to facilitate phosphorylation by BARK (By similarity). |
| Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity). |
| Protein Length | 418 Amino acids |
| Molecular weight | 46760 |
| Domain Name | 7tm_1 |
| References | 1 Liang W., Bidwell C.A., Williams S.K., Mills S.E.; "Molecular cloning of the porcine beta-2-adrenergic receptor gene."; Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
2 Li W.F., Nie C., Zhou X.X., Lu P., Yao J.T., Feng J.; "Molecular cloning of the porcine beta-2-adrenergic receptor gene."; Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
3 PubMed abstract 10229356
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| Hormone | N/A |
| Gene ID | 397357 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
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