A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20322 |
| Swiss-prot Accession number | P20905 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine receptor 1 (5-HT receptor) (Serotonin receptor 1)(5HT-dro). |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed predominantly in adult heads. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 564 Amino acids |
| Molecular weight | 60861 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 2174167 2 PubMed abstract 10731132 3 PubMed abstract 12537572 4 Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W.,Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,Celniker S.E.; Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. |
| Hormone | N/A |
| Gene ID | 43669 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |