A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20313 |
| Swiss-prot Accession number | P28221 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 1D receptor (5-HT-1D) (Serotonin receptor 1D) (5-HT-1D-alpha). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 377 Amino acids |
| Molecular weight | 41907 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1652050 2 PubMed abstract 1565658 3 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. 4 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 16710414 6 PubMed abstract 15489334 7 PubMed abstract 10391209 8 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
| Hormone | N/A |
| Gene ID | 3352 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |