A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20291 |
| Swiss-prot Accession number | P08908 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 1A receptor (5-HT-1A) (Serotonin receptor 1A) (5-HT1A) (G-21). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 422 Amino acids |
| Molecular weight | 46107 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 3041227 2 Saltzman A.G., Morse B., Felder S.; Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases. 3 Kitano T., Kobayakawa H., Saitou N.; "Silver project."; Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. 4 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 1766875 7 PubMed abstract 8393041 8 PubMed abstract 3138543 9 PubMed abstract 17203973 10 PubMed abstract 7755630 11 PubMed abstract 9754630 |
| Hormone | N/A |
| Gene ID | 3350 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |