A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11251
Swiss-prot Accession numberP01189 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
Function ACTH stimulates the adrenal glands to release cortisol
Protein Length267 Amino acids
Molecular weight29424
References1  PubMed abstract 6274691
2  PubMed abstract 6299668
3  PubMed abstract 6314261
4  PubMed abstract 15489334
5  PubMed abstract 3606677
6  PubMed abstract 6254047
7  PubMed abstract 6945581
8  PubMed abstract 6267033
9  PubMed abstract 6272808
10  PubMed abstract 4352834
11  PubMed abstract 14463577
12  PubMed abstract 15340161
13  PubMed abstract 4334191
14  PubMed abstract 4338630
15  PubMed abstract 4347148
16  PubMed abstract 1264228
17   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959).
18  PubMed abstract 195688
19  PubMed abstract 2424570
20  PubMed abstract 2839146
21  PubMed abstract 7828531
22  PubMed abstract 9620771
23  PubMed abstract 16046320
24  PubMed abstract 16807684
25  PubMed abstract 9768693
26  PubMed abstract 10193875
27  PubMed abstract 11244459
28  PubMed abstract 12165561
29  PubMed abstract 6274691
30  PubMed abstract 6299668
31  PubMed abstract 6314261
32  PubMed abstract 15489334
33  PubMed abstract 3606677
34  PubMed abstract 6254047
35  PubMed abstract 6945581
36  PubMed abstract 6267033
37  PubMed abstract 6272808
38  PubMed abstract 4352834
39  PubMed abstract 14463577
40  PubMed abstract 15340161
41  PubMed abstract 4334191
42  PubMed abstract 4338630
43  PubMed abstract 4347148
44  PubMed abstract 1264228
45   Harris J.I.; "Structure of a melanocyte-stimulating hormone from the humanpituitary gland."; Nature 184:167-169(1959).
46  PubMed abstract 195688
47  PubMed abstract 2424570
48  PubMed abstract 2839146
49  PubMed abstract 7828531
50  PubMed abstract 9620771
51  PubMed abstract 16046320
52  PubMed abstract 16807684
53  PubMed abstract 9768693
54  PubMed abstract 10193875
55  PubMed abstract 11244459
56  PubMed abstract 12165561
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameCorticotropin
Mature Hormone SequenceSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
Position of mature hormone in Pre-Hormone protein39 Residues from position (138-176)
ReceptorQ01726    Detail in HMRbase   
Gene ID5443      
PDB IDN/A
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