A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10800
Swiss-prot Accession numberP01317 (Sequence in FASTA format)
DescriptionInsulin precursor [Contains: Insulin B chain; Insulin A chain].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the insulin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Protein Length105 Amino acids
Molecular weight11393
References1  PubMed abstract 2456452
2  PubMed abstract 4928892
3  PubMed abstract 14886311
4  PubMed abstract 5545080
5  PubMed abstract 5105368
6  PubMed abstract 13032079
7  PubMed abstract 13249947
8   Smith G.D., Duax W.L., Dodson E.J., Dodson G.G., de Graaf R.A.G.,Reynolds C.D.; "The structure of des-Phe b1 bovine insulin."; Acta Crystallogr. B 38:3028-3032(1982).
9  PubMed abstract 9141131
Domain NameInsulin  
Hormone NameInsulin B chain
Mature Hormone SequenceFVNQHLCGSHLVEALYLVCGERGFFYTPKA
Position of mature hormone in Pre-Hormone protein30 Residues from position (25-54)
ReceptorN/A
Gene ID280829      
PDB ID1APH   1BPH   1CPH   1DPH   1HO0   1PID   2A3G   2BN1   2BN3   2INS      
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated