A database of hormones and their receptors
Peptide Hormone

Search Result - 1

HMRbase accession number11258
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Beta-endorphin is an endogenous opiate
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameBeta-endorphin
Mature Hormone SequenceYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
Position of mature hormone in Pre-Hormone protein31 Residues from position (235-265)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 2

HMRbase accession number11259
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameMelanotropin gamma (Gamma-MSH)
Mature Hormone SequenceYVMGHFRWDRF
Position of mature hormone in Pre-Hormone protein11 Residues from position (77-87)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 3

HMRbase accession number11260
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function ACTH stimulates the adrenal glands to release cortisol
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameCorticotropin
Mature Hormone SequenceSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEF
Position of mature hormone in Pre-Hormone protein39 Residues from position (132-170)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 4

HMRbase accession number11261
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameMelanotropin alpha (Alpha-MSH)
Mature Hormone SequenceSYSMEHFRWGKPV
Position of mature hormone in Pre-Hormone protein13 Residues from position (132-144)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 5

HMRbase accession number11262
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameLipotropin beta (Beta-LPH)
Mature Hormone SequenceELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
Position of mature hormone in Pre-Hormone protein93 Residues from position (173-265)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 6

HMRbase accession number11263
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameLipotropin gamma (Gamma-LPH)
Mature Hormone SequenceELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAEAAEKKDSGPYKMEHFRWGSPPKD
Position of mature hormone in Pre-Hormone protein60 Residues from position (173-232)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 7

HMRbase accession number11264
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameMelanotropin beta (Beta-MSH)
Mature Hormone SequenceDSGPYKMEHFRWGSPPKD
Position of mature hormone in Pre-Hormone protein18 Residues from position (215-232)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 8

HMRbase accession number11265
Swiss-prot Accession numberP01190 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Met-enkephalin is an endogenous opiate
Protein Length265 Amino acids
Molecular weight29260
References1  PubMed abstract 221818
2  PubMed abstract 6249166
3  PubMed abstract 6263630
4   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
5   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
6  PubMed abstract 216007
7  PubMed abstract 7274457
8  PubMed abstract 13642798
9   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
10  PubMed abstract 4344689
11   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
12   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
13  PubMed abstract 13348631
14  PubMed abstract 1065904
15  PubMed abstract 4030947
16  PubMed abstract 2266117
17  PubMed abstract 221818
18  PubMed abstract 6249166
19  PubMed abstract 6263630
20   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
21   Rubtsov P.M., Chernov B.K., Gorbulev V.G., Parsadanyan A.S.,Sverdlova P.S., Chupeeva V.V., Golova Y.B., Batchikova N.V.,Zhvirblis G.S., Skryabin K.G., Baev A.A.; "Genetic engineering of peptide hormones."; Mol. Biol. (Mosk.) 19:226-235(1985).
22  PubMed abstract 216007
23  PubMed abstract 7274457
24  PubMed abstract 13642798
25   Li C.H., Dixon J.S., Chung D.; "Isolation of melatonin, the pineal gland factor that lightensmelanocytes."; J. Am. Chem. Soc. 80:2587-2588(1958).
26  PubMed abstract 4344689
27   Pankov Y.A.; "Primary structure of the bovine beta-lipotropic hormone."; Vopr. Med. Khim. 19:330-332(1973).
28   Geschwind I.I., Li C.H., Barnafi L.; "The isolation and structure of a melanocyte-stimulating hormone frombovine pituitary glands."; J. Am. Chem. Soc. 79:1003-1004(1957).
29  PubMed abstract 13348631
30  PubMed abstract 1065904
31  PubMed abstract 4030947
32  PubMed abstract 2266117
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameMet-enkephalin
Mature Hormone SequenceYGGFM
Position of mature hormone in Pre-Hormone protein5 Residues from position (235-239)
ReceptorP47798    Detail in HMRbase   
Gene ID281416      
PDB IDN/A
Drugpediawiki
Comments