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4161 details
Primary information
Hemolytik ID4161
PMID15009528
YEAR2004
SEQUENCEVKLLVyPLKVKLyP
LENGTH14
NAMEGS14LL4
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITYMHC =3µg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCEEETTEEECCC
SMILESN[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEEffects of single D-amino acid substitutions on disruption of beta-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S.
AUTHORSLee DL,Powers JP,Pflegerl K,Vasil ML,Hancock RE
JOURNALJ Pept Res. 2004 Feb;63(2):69-84.