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4136 details
Primary information
Hemolytik ID4136
PMID10441158
YEAR1999
SEQUENCECGESCVFIPCISTLLGCSCKNKVCYRNGVIP
LENGTH30
NAMECirculin B
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryL
Modified ResiduesNone
FUNCTIONUterotonic
ACTIVITYHD50 =30μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCSSSSSSTHHHHHTTSCCCCCCCCCSSCC
SMILESN[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
2eriA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEChemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.
AUTHORSDaly NL,Love S, Alewood, P ,Alewood PF
JOURNALBiochemistry. 1999 Aug 10;38(32):10606-14.