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3668 details
Primary information
Hemolytik ID3668
PMID8810288
YEAR1996
SEQUENCEyPVKLKVyPLKVKL
LENGTH14
NAMEGS14
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAntibacterial
ACTIVITY100% hemolysis at 6µg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCCCCCCGGGSCC
SMILESN[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEModulation of structure and antibacterial and hemolytic activity by ring size in cyclic gramicidin S analogs.
AUTHORSKondejewski LH,Farmer SW,Wishart DS,Kay CM,Hancock RE
JOURNALJ Biol Chem. 1996 Oct 11;271(41):25261-8.