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3608 details
Primary information
Hemolytik ID3608
PMID22074926
YEAR2012
SEQUENCECGESCVFIPCITSLAGCSCKNKVCYYDGGSVP
LENGTH32
NAMEParigidin_br1
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITY28% hemolysis at 20µM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCCCCCCSSSSSSSSSCCCCCCCCCTTTSCC
SMILESN[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEIdentification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane.
AUTHORSPinto MF,Fensterseifer IC,Migliolo L,Sousa DA,de Capdville G,Arboleda-Valencia JW,Colgrave ML,Craik DJ,Magalhaes BS,Dias SC
JOURNALJ Biol Chem. 2012 Jan 2;287(1):134-47. doi: 10.1074/jbc.M111.294009. Epub 2011 Nov 10.