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3569 details
Primary information
Hemolytik ID3569
PMID18519720
YEAR2008
SEQUENCEAGYLLGKINLKALAALAKKIL
LENGTH21
NAMETP10
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITY5% hemolysis at 30μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCSCCCSSCHHHHHHHHHTTC
SMILESN[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA 1smzA
from
7
TO
27		 NA NA NA NA NA NA
Reference Informaiton
ARTICLECell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.
AUTHORSArrighi RB,Ebikeme C,Jiang Y,Ranford-Cartwright L,Barrett MP,Langel U
JOURNALAntimicrob Agents Chemother. 2008 Sep;52(9):3414-7. doi: 10.1128/AAC.01450-07. Epub 2008 Jun 2.