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3252 details
Primary information
Hemolytik ID3252
PMID23328867
YEAR2013
SEQUENCETHRPPMWSPVWPGGGKLlLKlLkkLLKlLKKK
LENGTH32
NAMETfR-lytic hybrid peptide
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAnticancer
ACTIVITY17% hemolysis at 100μM
RBCs SOURCEMouse
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCBTTBSSSSSCCCTHHHHHHHHHHHHHHHHC
SMILESN[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEImmunogenicity and toxicity of transferrin receptor-targeted hybrid peptide as a potent anticancer agent.
AUTHORSKawamoto M,Kohno M,Horibe T
JOURNALCancer Chemother Pharmacol. 2013 Mar;71(3):799-807. doi: 10.1007/s00280-013-2074-4. Epub 2013 Jan 18.