Primary information |
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Hemolytik ID | 3207 |
PMID | 22974815 |
YEAR | 2013 |
SEQUENCE | FVPWFSKfLGRIL |
LENGTH | 13 |
NAME | [Pro3, DPhe8]TL |
C-ter Modification | Amidation |
N-ter Modification | Free |
Linear/Cyclic | Linear |
Stereochemistry | Mix (Contains both L and D amino acids) |
Modified Residues | None |
FUNCTION | Antimicrobial |
ACTIVITY | 19% hemolysis at 24μM |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CCCTTTSSSSCCC |
SMILES | N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
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Reference Informaiton |
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ARTICLE | The effect of d-amino acid substitution on the selectivity of temporin L towards target cells: identification of a potent anti-Candida peptide. |
AUTHORS | Grieco P,Carotenuto A,Auriemma L,Saviello MR,Campiglia P,Gomez-Monterrey IM,Marcellini L,Luca V,Barra D,Novellino E |
JOURNAL | Biochim Biophys Acta. 2013 Feb;1828(2):652-60. doi: 10.1016/j.bbamem.2012.08.027. Epub 2012 Sep 10. |