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3015 details
Primary information
Hemolytik ID3015
PMID21576247
YEAR2011
SEQUENCEGLPVCGETCVGGTCNTPGCTCSWPVCTRN
LENGTH29
NAMEacyclic
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONHemolytic and Anti-HIV
ACTIVITY2.8±0.3% hemolytic at 25μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCCCSSHHHHCCCCCSSCCCCSSCCSCC
SMILESNCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
2khbA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEDecoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities.
AUTHORSHenriques ST,Huang YH,Rosengren KJ,Franquelim HG,Carvalho FA,Johnson A,Sonza S,Tachedjian G,Castanho MA,Daly NL
JOURNALJ Biol Chem. 2011 Jul 8;286(27):24231-41. doi: 10.1074/jbc.M111.253393. Epub 2011 May 16.