Primary information |
---|
Hemolytik ID | 3010 |
PMID | 21576247 |
YEAR | 2011 |
SEQUENCE | GLPVCGETCVGGTCNTPGCTCSWPKCTRN |
LENGTH | 29 |
NAME | V25K |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Cyclic |
Stereochemistry | L |
Modified Residues | None |
FUNCTION | Hemolytic and Anti-HIV |
ACTIVITY | 1.1±1.0% hemolytic at 25μM |
RBCs SOURCE | Human |
Secondary information |
---|
Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CCSSCSCTTTTTTSCCCCCSSCCSSCCCC |
SMILES | NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O |
External Links |
---|
PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
|
Reference Informaiton |
---|
ARTICLE | Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. |
AUTHORS | Henriques ST,Huang YH,Rosengren KJ,Franquelim HG,Carvalho FA,Johnson A,Sonza S,Tachedjian G,Castanho MA,Daly NL |
JOURNAL | J Biol Chem. 2011 Jul 8;286(27):24231-41. doi: 10.1074/jbc.M111.253393. Epub 2011 May 16. |