Primary information |
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Hemolytik ID | 3008 |
PMID | 21576247 |
YEAR | 2011 |
SEQUENCE | GLPVCGETCVGGTCNKPGCTCSWPVCTRN |
LENGTH | 29 |
NAME | T16K |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Cyclic |
Stereochemistry | L |
Modified Residues | None |
FUNCTION | Hemolytic and Anti-HIV |
ACTIVITY | 4.3±0.1% hemolytic at 25μM |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CCSSTTSCSHHHHSSSTTCSCCCCGGGGC |
SMILES | NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
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Reference Informaiton |
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ARTICLE | Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities. |
AUTHORS | Henriques ST,Huang YH,Rosengren KJ,Franquelim HG,Carvalho FA,Johnson A,Sonza S,Tachedjian G,Castanho MA,Daly NL |
JOURNAL | J Biol Chem. 2011 Jul 8;286(27):24231-41. doi: 10.1074/jbc.M111.253393. Epub 2011 May 16. |