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  HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

Detailed description page of Hemolytik

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2960 details
Primary information
Hemolytik ID2960
PMID21820306
YEAR2011
SEQUENCEtle-K-tle-A-tle-A-tle-A
LENGTH8
NAMEA
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesTle=Tert-leucine
FUNCTIONAntimicrobial
ACTIVITYNo hemolytic at 100μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesNA
SMILESNA
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEPharmacodynamic synergy strictly dependent on the co-operative aggregation of enantiomers of cyclic peptides in the bacterial cell membrane.
AUTHORSDanielsson M,Rosenthal-Aizman K,Bergsson G
JOURNALBioorg Med Chem Lett. 2011 Sep 15;21(18):5262-5. doi: 10.1016/j.bmcl.2011.07.032. Epub 2011 Jul 19.