Primary information |
---|
Hemolytik ID | 2926 |
PMID | 21729875 |
YEAR | 2011 |
SEQUENCE | GWKSVFRKAKKVGKTVGGLALDHYL |
LENGTH | 25 |
NAME | NRC-11 |
C-ter Modification | Amidation |
N-ter Modification | Free |
Linear/Cyclic | Linear |
Stereochemistry | L |
Modified Residues | None |
FUNCTION | Anticancer |
ACTIVITY | 50% hemolytic at >256μg/ml |
RBCs SOURCE | Human |
Secondary information |
---|
Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CCGGGHHHHCCCCCCSSSSCSSCCC |
SMILES | NCC(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O |
External Links |
---|
PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
|
Reference Informaiton |
---|
ARTICLE | The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. |
AUTHORS | Morash MG,Douglas SE,Robotham A,Ridley CM,Gallant JW |
JOURNAL | Dis Model Mech. 2011 Sep;4(5):622-33. doi: 10.1242/dmm.007310. Epub 2011 Jul 4. |