Primary information |
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Hemolytik ID | 2839 |
PMID | 21319749 |
YEAR | 2011 |
SEQUENCE | FVQWFSKFLGKIL |
LENGTH | 13 |
NAME | [Lys11]TL |
C-ter Modification | Amidation |
N-ter Modification | Free |
Linear/Cyclic | Linear |
Stereochemistry | L |
Modified Residues | None |
FUNCTION | Antimicrobial |
ACTIVITY | 14% hemolytic at 6μM |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CHHHHHHHHTCCC |
SMILES | N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
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Reference Informaiton |
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ARTICLE | Structure-activity relationship, conformational and biological studies of temporin L analogues. |
AUTHORS | Mangoni ML,Carotenuto A,Auriemma L,Saviello MR,Campiglia P,Gomez-Monterrey I,Malfi S,Marcellini L,Barra D,Novellino E |
JOURNAL | J Med Chem. 2011 Mar 10;54(5):1298-307. doi: 10.1021/jm1012853. Epub 2011 Feb 14. |