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2837 details
Primary information
Hemolytik ID2837
PMID21319749
YEAR2011
SEQUENCEFVPWFSKFLPRIL
LENGTH13
NAME[Pro3, Pro10]TL
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITY4.5% hemolytic at 6μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCCGGGTSSSCC
SMILESN[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEStructure-activity relationship, conformational and biological studies of temporin L analogues.
AUTHORSMangoni ML,Carotenuto A,Auriemma L,Saviello MR,Campiglia P,Gomez-Monterrey I,Malfi S,Marcellini L,Barra D,Novellino E
JOURNALJ Med Chem. 2011 Mar 10;54(5):1298-307. doi: 10.1021/jm1012853. Epub 2011 Feb 14.