Primary information |
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Hemolytik ID | 2796 |
PMID | 20848624 |
YEAR | 2010 |
SEQUENCE | FP-tBuGly-O-tBuAla-fP-tBuGly-O-tBuAla |
LENGTH | 10 |
NAME | GS7 |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Cyclic |
Stereochemistry | Mix (Contains both L and D amino acids) |
Modified Residues | Ornithine, tBuGly= tert-butylglycine, tBuAla=tert-butylalanine |
FUNCTION | Antimicrobial |
ACTIVITY | HC50 =9.30±1.07μM |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | NA |
SMILES | NA |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
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Reference Informaiton |
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ARTICLE | An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity. |
AUTHORS | Kapoerchan VV,Knijnenburg AD,Niamat M,Spalburg E,de Neeling AJ,Nibbering PH,Mars-Groenendijk RH,Noort D,Otero JM,Llamas-Saiz AL,van Raaij MJ,van der Marel GA,Overkleeft HS |
JOURNAL | Chemistry. 2010 Oct 25;16(40):12174-81. doi: 10.1002/chem.201001686. |