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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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2705 details
Primary information
Hemolytik ID2705
PMID22328546
YEAR2012
SEQUENCEGIGAILKVLATGLPTLISWIKNKRKQ
LENGTH26
NAMEFlorae
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONCPP
ACTIVITY~80% hemolytic at 25μM at pH 8
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCTTSHHHHTTTSHHHHHHHHTTCCC
SMILESNCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA P01504 NA NA NA NA NA
Reference Informaiton
ARTICLETruncated peptides from melittin and its analog with high lytic activity at endosomal pH enhance branched polyethylenimine-mediated gene transfection.
AUTHORSTan YX,Chen C,Wang YL,Lin S,Wang Y,Li SB,Jin XP,Gao HW,Du FS,Gong F
JOURNALJ Gene Med. 2012 Apr;14(4):241-50. doi: 10.1002/jgm.2609.